Description
PA1 is a component of a Set1-like multiprotein histone methyltransferase complex. It interacts with PAXIP1/PTIP; the interaction is direct and is required for the association with the rest of the PTIP complex. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. Recombinant human PA1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques